We found that the TCR clonality of tissues was related to smoking, with higher clonality in patients who had quit smoking for less than 1 year. To comprehensively profile the TCR repertoire, results from high-throughput sequencing of samples from 93 Chinese patients with lung cancer were analyzed. This study aimed to determine the characteristics and clinical significance of the TCR repertoire in lung cancer. Sequencing of the T-cell receptor (TCR) repertoire can reveal the immunosurveillance status of the tumor microenvironment, which is related to tumor escape and immunotherapy. Lung cancer is the leading cause of cancer-related deaths worldwide, and its occurrence is related to the accumulation of gene mutations and immune escape of the tumor. 5Medical Center, Geneplus-Beijing Institute, Beijing, China.4Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.3Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.2Department of Thoracic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.1Department of Rheumatology and Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.Huaxia Yang 1† Yadong Wang 2,3† Ziqi Jia 2,4† Yanyu Wang 2,3 Xiaoying Yang 2,4 Pancheng Wu 2,3 Yang Song 2 Huihui Xu 2 Dejian Gu 5 Rongrong Chen 5 Xuefeng Xia 5 Zhongxing Bing 2 Chao Gao 2 Lei Cao 2 Shanqing Li 2 Zhili Cao 2* Naixin Liang 2*
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